April 11, 2017

Team Members- Department of Infection and Immunology

 

 

Anurag Adhikari

Research Head/Group Leader, Department of Infection and Immunology

Email: adhikari.a[at]kribs.org.np

Twitter,  ORCID 

 

Education

Ph.D. in Immunology (Pathology), University of New South Wales, Australia

Bachelor of Technology in Biotechnology, Purbanchal University, Nepal

Bio

Anurag Adhikari is an immunologist, currently working on the functional aspect of human adaptive immunity. He studies the polyclonal antibody effector functions to characterize the humoral immunity in viral infection. He is currently adapting the antibody effector functional assays like the antibody-dependent cellular phagocytosis (ADCP),  antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent neutralization (ADN), to understand the role of anti-HIV antibodies in HIV pathogenesis and disease. In addition to HIV, he is currently working to understand the humoral and innate immune response against the bacteria Orientia tsutsugamushi, which causes Scrub typhus disease in humans. Understanding the anti-bacterial antibody induction, associated inflammatory cytokine response, and bacterial evolution among acute febrile patients in the endemic community is the primary outcome of this study.

Apart from humoral immunology during infection, he has a special interest in pathogen-specific B cell induction, maintenance, and proliferation after infection and immunization.  In this aspect, he is currently leading the KRIBS anti-Viral Antibody discovery (KaVA)-program to understand the induction and persistence of HIV-specific B cells, to support the research and development of next-generation of anti-HIV therapeutic antibodies and effective vaccines against HIV.

More details are in KaVA-Program [see  https://kribs.org.np/kava-program/]

 

Publications

Google Scholar Publication List

 

 


Minu Singh

Research Associate/Programs Manager

Email: singh.m@kribs.org.np

 

Education

MSc. Biotechnology, Banaras Hindu University

Bachelor of Technology in Biotechnology, Purbanchal University, Nepal

Publications

Google Scholar Publication List


 

Adesh Baral

Research Assistant

Email: baral.a@kribs.org.np

 

 

 

Education

B.Tech in Biotechnology, Kathmandu University



  • Supervisory team


Binod Rayamajhee

Research Fellow

Email: binod@kribs.org.np

Twitter

Education

Ph.D., Optometry, University of New South Wales, Australia

Bio

Binod Rayamajhee is investigating the severity of a devastating eye infection, Acanthamoeba keratitis (AK), using cutting-edge molecular techniques, that can lead to blindness and even eye removal. Binod is examining the incidence and type of microbial endosymbionts in clinical and environmental isolates of Acanthamoeba using deep-sequencing techniques and determining whether these different endosymbionts affect the course of ocular infection and the ability to treat Acanthamoeba infection in an animal model. In addition, Binod also worked with infectious diseases such as Scrub Typhus, nosocomial infections, the impact of climate change on vector-borne diseases with further interests in investigating the burden of antimicrobial resistance (AMR) from One Health Perspective.

Publications

Google Scholar Publication List

 


Rajesh Chaudhary

Research Fellow

Email: rajeshchaudhary.np@gmail.com

 

Education

PhD in Medicine, South Australian Health and Medical Research Institute (SAHMRI) and Adelaide
Health and Medical School, The University of Adelaide, Australia
M.Sc. Medical Biochemistry, Siriraj Hospital, Mahidol University, Thailand
B.Tech in Biotechnology, School of Science, Kathmandu University, Nepal

Bio

My research interest focuses on understanding the complex network of obesity-related pathological conditions such as diabetes, cardiovascular, liver, and muscle diseases in relation to autophagy and mitochondrial health and their response under various nutritional intervention states. During my last eight years of research work in Nepal, Thailand, and Australia, I have tried to understand the range of pathological conditions that feed into the process and amplify obesity-associated pathological conditions from physiological to molecular levels. In my upcoming projects, I will be engaged in understanding the behavior of our immune system after myocardial infarction and their role in allograft vasculopathy, including understanding the dynamics of inflammatory milieu after allograft and their contribution in allograft rejection.

Publications

Google Scholar Publication List

 

 


  • Department of Infection and Immunology Current Research Students/Interns



 

 

 

 

 

Prawesh Mohan Bhattarai [Undergraduate Thesis student, January 2022-Present]

Research study: Impaired mycobacterium protein derivate specific IFN-γ response among Nepalese HIV patients

Supervisor: Anurag Adhikari

Google Scholar,  Twitter


 

 

 

 

Sushmita Theeng [Undergraduate Thesis student, April  2022-Present]

Research study: Optimization and validation of interferon-gamma based ELISpot utilizing peripheral blood mononuclear cells.

Supervisor: Anurag Adhikari


 

 

 

 

 

Sauhardra Manandhar [Undergraduate Thesis student, April  2022-Present]

Research study:Optimization and validation of interferon-gamma based ELISpot utilizing peripheral blood mononuclear cells.

Supervisor: Anurag Adhikari


 

 

 

 

 

Shristi Shrestha [Undergraduate Thesis student, April  2022-Present]

Research study: Optimization and validation of interferon-gamma based ELISpot utilizing peripheral blood mononuclear cells.

Supervisor: Anurag Adhikari


 

 

 

 

 

Srijana Niraula [Undergraduate Thesis student, April  2022-Present]

Research study: Optimization and validation of interferon-gamma based ELISpot utilizing peripheral blood mononuclear cells.

Supervisor: Anurag Adhikari


 

 

 

 

 

Nisha Thapa [Research Intern, May  2022-Present]

Google Scholar, Twitter

Research study:

(a) Characterization of adaptive immunity in Human Immunodeficiency Virus (HIV) infection.

(b) Development of lymphatic filariasis database: a national Spatio-temporal resource.

(c) Development and optimization of the mammalian protein expression and purification system.

Supervisor: Anurag Adhikari



  • Department of Infection and Immunology Alumni


 

 

 

 

 

 

Divyashree Thapa (Science communication intern, July 2022-August 2022)

Supervisor: Anurag Adhikari


Namuna Ghimire [Intern, August 2021-February 2022]

Research study: Development of lymphatic filariasis database: a national Spatio-temporal resource

Supervisor: Anurag Adhikari


Krisha Subedi [Science communication intern, August 2021-December 2021]

Supervisor: Anurag Adhikari


Prakriti Karki [Intern, March 2021-December 2021]

Research study: Characterization of anti-HIV antibodies for their role in immune effector (neutralizing and Fc mediated) functions

Supervisor: Anurag Adhikari

 

 



  • Department of Infection and Immunology Advisory Board

Daisy Awale

Gaurab Karki

Ashmita Timilsina

Amina Bania

Sushma Singh

Binod GC

Pratik Koirala