April 11, 2017

Team Members- Department of Infection and Immunology

 

Anurag Adhikari

Research Head/Group Leader, Department of Infection and Immunology

adhikari.a@kribs.org.np

Google Scholar,  Twitter,  ORCID 

Education

Ph.D, Immunology (Pathology), University of New South Wales, Australia

Bachelor of Technology in Biotechnology, Purbanchal University, Nepal

Bio

Anurag Adhikari is currently working on functional aspect of human adaptive immunity. His research utilizes the polyclonal antibody Fc effector function to understand role of humoral immunity during viral diseases so as to understand how it primes innate immunity early in the infection cascade. He has developed the antibody assay platform to understand Fc effector function of antibodies produced during Hepatitis C virus and SARS CoV-2 infection.  He is currently adapting the assay of antibody-dependent cellular phagocytosis (ADCP),  antibody-dependent cellular cytotoxicity (ADCC), and antibody dependent neutralization (ADN) to understand HIV-1 pathogenesis. Additionally, he has worked with neglected tropical diseases like Dengue, and is currently working to understand the parasitic disease Lymphatic Filariasis burden in Nepal. In addition to functional immunology during infection, he also has a special interest in B cell ontogeny and how it is affected by germinal center remodulation during infection and immunization.  Apart from infection, he is also equally interested in non-communicable disease immune pathology including of the diabetes and auto immune disorders.

Publications

NCBI Bibliography Link

 

 

 

Minu Singh

Research Associate, Department of Infection and Immunology

singh.m@kribs.org.np

 

Education

MSc. Biotechnology, Banaras Hindu University

Bachelor of Technology in Biotechnology, Purbanchal University, Nepal

 

Bio

I am interested in infection and immunology and I aim to utilize this knowledge to understand the modalities of human diseases. I am also interested in vaccine development and therapeutics against viral pathogens specifically against those chronic disease inducing pathogens including Human Immunodeficiency Virus and Hepatitis C Virus.

 

 

 


Gaurab Karki

My primary research interest is the intersection between immunology and virology focusing on design, and preclinical evaluation of vaccines targeting emerging viral pathogens. I am also interested in analysis and characterization of outbreak strain, molecular analysis of drug resistant gene and track down the dissemination of resistance through horizontal gene transfer among bacterial population.

NCBI Bibliography Link

 

Binod G.C

My research aims to understand the molecular mechanisms involved in the regulation of blood cell development in the bone marrow and why disruption in these mechanisms leads to blood malignancies, such as leukemia and lymphoma. Gfi1, an important regulator of hematopoiesis is what I am interested in specifically. Gfi1 is a transcriptional regulator that has a very important role in white blood cells development including myeloid and lymphoid cells. Gfi1 has role in stem cell renewal, blood cells survival, proliferation and differentiation. Study of Hemgn, another potential leukemogenic gene having role in Hematopoietic stem cell renewal, Erythroid and Megakaryocytic cells differentiation, is also a project I am working on currently. The study of these oncogenic transcription factors can aid in developing novel therapeutic approach in treatment of different blood malignancies.

Binod Rayamajhee

My current work is about microbial keratitis focusing on Acanthamoeba keratitis and my research is diving to assess the role of amoeba genotypes and it’s microbiome in the severity of the corneal infection. My research interest includes contact lens associated eye infections, antimicrobial-resistance, disease surveillance, interspecies transmission of disease, and molecular diagnosis of infectious diseases.

 

 

Pratik Koirala

I am currently working towards finding the mechanism by which antibiotic resistance is controlled by quorum sensing in beta-proteobacteria. My research focuses on quorum sensing controlled expression of a multidrug efflux pump. Why does the bacteria express the efflux pump only after QS is turned on and why is it not expressed constitutively? Answering this question is the focus of my research which will help us target the QS system as a novel target for antibiotics in the future.

 

 

Ashmita Timilsina

 

 

 

 

Amina Baniya

 

 

 

 

 

Daisy Awale

 

 

 

 

 

Manjula Bhattarai

 

 

 

 

 

Sushma Singh