Anurag Adhikari Research Head/Group Leader, Department of Infection and Immunology adhikari.a@kribs.org.np Google Scholar, Twitter, ORCID Education Ph.D, Immunology (Pathology), University of New South Wales, Australia Bachelor of Technology in Biotechnology, Purbanchal University, Nepal Bio Anurag Adhikari is currently working on functional aspect of human adaptive immunity. His research utilizes the polyclonal antibody Fc effector function to understand role of humoral immunity during viral diseases so as to understand how it primes innate immunity early in the infection cascade. He has developed the antibody assay platform to understand Fc effector function of antibodies produced during Hepatitis C virus and SARS CoV-2 infection. He is currently adapting the assay of antibody-dependent cellular phagocytosis (ADCP), antibody-dependent Publications |
|
|
|
Minu Singh Research Associate, Department of Infection and Immunology singh.m@kribs.org.np
Education MSc. Biotechnology, Banaras Hindu University Bachelor of Technology in Biotechnology, Purbanchal University, Nepal
Bio I am interested in infection and immunology and I aim to utilize this knowledge to understand the modalities of human diseases. I am also interested in vaccine development and therapeutics against viral pathogens specifically against those chronic disease inducing pathogens including Human Immunodeficiency Virus and Hepatitis C Virus.
Gaurab Karki
Binod G.C
Binod Rayamajhee
Pratik Koirala
Ashmita Timilsina
Amina Baniya
Daisy Awale
Manjula Bhattarai
Sushma Singh
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
My primary research interest is the intersection between immunology and virology focusing on design, and preclinical evaluation of vaccines targeting emerging viral pathogens. I am also interested in analysis and characterization of outbreak strain, molecular analysis of drug resistant gene and track down the dissemination of resistance through horizontal gene transfer among bacterial population.
My research aims to understand the molecular mechanisms involved in the regulation of blood cell development in the bone marrow and why disruption in these mechanisms leads to blood malignancies, such as leukemia and lymphoma. Gfi1, an important regulator of hematopoiesis is what I am interested in specifically. Gfi1 is a transcriptional regulator that has a very important role in white blood cells development including myeloid and lymphoid cells. Gfi1 has role in stem cell renewal, blood cells survival, proliferation and differentiation. Study of Hemgn, another potential leukemogenic gene having role in Hematopoietic stem cell renewal, Erythroid and Megakaryocytic cells differentiation, is also a project I am working on currently. The study of these oncogenic transcription factors can aid in developing novel therapeutic approach in treatment of different blood malignancies.
My current work is about microbial keratitis focusing on Acanthamoeba keratitis and my research is diving to assess the role of amoeba genotypes and it’s microbiome in the severity of the corneal infection. My research interest includes contact lens associated eye infections, antimicrobial-resistance, disease surveillance, interspecies transmission of disease, and molecular diagnosis of infectious diseases.
I am currently working towards finding the mechanism by which antibiotic resistance is controlled by quorum sensing in beta-proteobacteria. My research focuses on quorum sensing controlled expression of a multidrug efflux pump. Why does the bacteria express the efflux pump only after QS is turned on and why is it not expressed constitutively? Answering this question is the focus of my research which will help us target the QS system as a novel target for antibiotics in the future.
